Trim24^tm1.2Mcba
Targeted Allele Detail

Summary

• Symbol: Trim24^tm1.2Mcba
• Name: tripartite motif-containing 24; targeted mutation 1.2, Michelle Craig Barton
• MGI ID: MGI:6857763
• Gene: Trim24 Location: Chr6:37847746-37943231 bp, + strand Genetic Position: Chr6, 17.07 cM, cytoband B1
• Alliance: Trim24^tm1.2Mcba page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:317520
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 1 and a loxP site and FRT flanked neo cassette were inserted downstream of exon 1 via homologous recombination. Flp and cre mediated recombination removed the neo cassette and exon 1. (J:317520)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trim24 Mutation: 100 strains or lines available

References

• Original: J:317520 Jiang S, et al., TRIM24 suppresses development of spontaneous hepatic lipid accumulation and hepatocellular carcinoma in mice. J Hepatol. 2015 Feb;62(2):371-9
• All: 1 reference(s)