Foxm1^tm1.2Rhc
Targeted Allele Detail

Summary

• Symbol: Foxm1^tm1.2Rhc
• Name: forkhead box M1; targeted mutation 1.2, Robert H Costa
• MGI ID: MGI:6857756
• Synonyms: Foxm1b fl
• Gene: Foxm1 Location: Chr6:128339957-128352849 bp, + strand Genetic Position: Chr6, 62.98 cM
• Alliance: Foxm1^tm1.2Rhc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:101977
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A single loxP site was introduced into intron 3 and a floxed PGK-neo cassette was introduced downstream of exon 7 through homologous recombination. Cre-mediated recombination removed the loxP-flanked neomycin cassette leaving a single loxP site downstream of exon 7. Selected mice retained loxP sites flanking exons 4-7. (J:81015)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Foxm1 Mutation: 26 strains or lines available

Notes

The version of this allele that contains the neomycin selection cassette, Foxm1^tm1Rhc, has been analyzed.

References

• Original: J:81015 Wang X, et al., The Forkhead Box m1b transcription factor is essential for hepatocyte DNA replication and mitosis during mouse liver regeneration. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16881-6
• All: 2 reference(s)