Thra^tm2Brnt
Targeted Allele Detail

Summary

• Symbol: Thra^tm2Brnt
• Name: thyroid hormone receptor alpha; targeted mutation 2, Gregory A Brent
• MGI ID: MGI:6856815
• Synonyms: THRA K283Q/K288R
• Gene: Thra Location: Chr11:98631539-98659832 bp, + strand Genetic Position: Chr11, 62.58 cM, cytoband D-E
• Alliance: Thra^tm2Brnt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:317730
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutation: Single point mutation
• Mutation details: The mutations in the Thra gene were introduced located at 1367nt (A to C) and 1381 nt (A to G) based on NCBI accession # NM_178060.4. The allele was generated using FLP/FRT recombinase-mediated cassette exchange techniques. (J:317730)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Thra Mutation: 39 strains or lines available

References

• Original: J:317730 Liu YY, et al., Thyroid hormone receptor alpha sumoylation modulates white adipose tissue stores. Sci Rep. 2021 Dec 16;11(1):24105
• All: 1 reference(s)