Loxl1^tm1.1Smoc
Targeted Allele Detail

Summary

• Symbol: Loxl1^tm1.1Smoc
• Name: lysyl oxidase-like 1; targeted mutation 1.1, Shanghai Model Organisms Center
• MGI ID: MGI:6856813
• Synonyms: Loxl1^fl
• Gene: Loxl1 Location: Chr9:58195021-58220469 bp, - strand Genetic Position: Chr9, 31.65 cM
• Alliance: Loxl1^tm1.1Smoc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:317721
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6JSmoc

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The targeting vector was designed to insert a loxP and an FRT flanked pGK-Neomycine-polyA cassette upstream of the exon1 of the Loxl1 genomic sequence and insert another loxP after the exon1. The neo cassette was removed by Flp recombinase. (J:317721)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Loxl1 Mutation: 37 strains or lines available

References

• Original: J:317721 Yang A, et al., Selective depletion of hepatic stellate cells-specific LOXL1 alleviates liver fibrosis. FASEB J. 2021 Oct;35(10):e21918
• All: 1 reference(s)