Dao^em1Ament
Endonuclease-mediated Allele Detail

Summary

• Symbol: Dao^em1Ament
• Name: D-amino acid oxidase; endonuclease-mediated mutation 1, Seth Ament
• MGI ID: MGI:6856679
• Gene: Dao Location: Chr5:114141764-114163743 bp, + strand Genetic Position: Chr5, 55.93 cM
• Alliance: Dao^em1Ament page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Single point mutation
• Mutation details: CRISPR-targeting of exon 5 introduced a point mutation (GGC to GTC) resulting in the amino acid substitution glycine with valine at position 130 (G130V). (J:350153)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Dao Mutation: 27 strains or lines available

References

• Original: J:350153 Hasin N, et al., Rare variants implicate NMDA receptor signaling and cerebellar gene networks in risk for bipolar disorder. Mol Psychiatry. 2022 Sep;27(9):3842-3856
• All: 1 reference(s)