Grik5^tm1.1Ksak
Targeted Allele Detail

Summary

• Symbol: Grik5^tm1.1Ksak
• Name: glutamate receptor, ionotropic, kainate 5 (gamma 2); targeted mutation 1.1, Kenji Sakimura
• MGI ID: MGI:6856661
• Gene: Grik5 Location: Chr7:24709274-24771771 bp, - strand Genetic Position: Chr7, 13.73 cM
• Alliance: Grik5^tm1.1Ksak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:317629
• Parent Cell Line: RENKA (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site and an FRT-flanked neomycin selection cassette were inserted 411 bp upstream of exon 13 and a second loxP site was inserted 96 bp downstream of exon 15. Exons 13 to 15 and the selection cassette were removed via cre-mediated recombination. (J:231108)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Grik5 Mutation: 50 strains or lines available

References

• Original: J:317629 Iida I, et al., A comparative analysis of kainate receptor GluK2 and GluK5 knockout mice in a pure genetic background. Behav Brain Res. 2021 May 7;405:113194
• All: 2 reference(s)