Kcnk2^tm1.1Lzd
Targeted Allele Detail

Summary

• Symbol: Kcnk2^tm1.1Lzd
• Name: potassium channel, subfamily K, member 2; targeted mutation 1.1, Michel Lazdunski
• MGI ID: MGI:6856516
• Synonyms: TREK-1 flox
• Gene: Kcnk2 Location: Chr1:188940127-189134470 bp, - strand Genetic Position: Chr1, 94.22 cM
• Alliance: Kcnk2^tm1.1Lzd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:91531
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The targeting vector is designed to insert a loxP site upstream of exon 3, and a PGK-neo cassette followed by a second loxP site just downstream of exon 3. (J:91531)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kcnk2 Mutation: 35 strains or lines available

References

• Original: J:91531 Heurteaux C, et al., TREK-1, a K(+) channel involved in neuroprotection and general anesthesia. EMBO J. 2004 Jul 7;23(13):2684-95
• All: 2 reference(s)