Il17f^em1Gaff
Endonuclease-mediated Allele Detail

Summary

• Symbol: Il17f^em1Gaff
• Name: interleukin 17F; endonuclease-mediated mutation 1, Sarah Gaffen
• MGI ID: MGI:6852749
• Synonyms: Il17f^S65L
• Gene: Il17f Location: Chr1:20847370-20855498 bp, - strand Genetic Position: Chr1, 6.49 cM
• Alliance: Il17f^em1Gaff page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Single point mutation
• Mutation details: CRISPR-targeting introduced the mutation that produces the amino acid substitution of serine with leucine at position 65 (S65L). (J:300395)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Il17f Mutation: 27 strains or lines available

References

• Original: J:300395 Zhou C, et al., An IL-17F.S65L Knock-In Mouse Reveals Similarities and Differences in IL-17F Function in Oral Candidiasis: A New Tool to Understand IL-17F. J Immunol. 2020 Aug 1;205(3):720-730
• All: 1 reference(s)