Gja1^em1Pdl
Endonuclease-mediated Allele Detail

Summary

• Symbol: Gja1^em1Pdl
• Name: gap junction protein, alpha 1; endonuclease-mediated mutation 1, Paul Lampe
• MGI ID: MGI:6852707
• Gene: Gja1 Location: Chr10:56253297-56266519 bp, + strand Genetic Position: Chr10, 28.64 cM
• Alliance: Gja1^em1Pdl page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Not Applicable)
• Mutation: Nucleotide substitutions
• Mutation details: CRISPR-targeting mutated the sequence encoding the Akt phosphorylation sites from serine to alanine (S365 and S373), rendering them unphosphorylatable. (J:94077)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gja1 Mutation: 59 strains or lines available

References

• Original: J:94077 Mutant Mouse Regional Resource Centers, Information obtained from the Mutant Mouse Regional Resource Centers (MMRRC). Unpublished. 2004-2015
• All: 1 reference(s)