Cgas^em1Kern
Endonuclease-mediated Allele Detail

Summary

• Symbol: Cgas^em1Kern
• Name: cyclic GMP-AMP synthase; endonuclease-mediated mutation 1, Nagaraj Kerur
• MGI ID: MGI:6852701
• Synonyms: cGASGS198AA, cGAS^GS198AA
• Gene: Cgas Location: Chr9:78337808-78350519 bp, - strand Genetic Position: Chr9, 43.65 cM
• Alliance: Cgas^em1Kern page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Not Applicable)
• Mutation: Nucleotide substitutions
• Mutation details: CRISPR/Cas9 technology generated a glycine to alanine and serine to alanine substitutions at amino acids 198 and 199 (GS198AA), generating a catalytically dead protein product. (J:314477)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cgas Mutation: 23 strains or lines available

References

• Original: J:314477 Banerjee D, et al., A non-canonical, interferon-independent signaling activity of cGAMP triggers DNA damage response signaling. Nat Commun. 2021 Oct 27;12(1):6207
• All: 2 reference(s)