C9orf72^tm1.1Past
Targeted Allele Detail

Summary

• Symbol: C9orf72^tm1.1Past
• Name: C9orf72, member of C9orf72-SMCR8 complex; targeted mutation 1.1, Jeroen Pasterkamp
• MGI ID: MGI:6852681
• Synonyms: C9orf72^loxP
• Gene: C9orf72 Location: Chr4:35191285-35226153 bp, - strand Genetic Position: Chr4, 17.13 cM
• Alliance: C9orf72^tm1.1Past page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:298381
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting construct was designed to insert an FRT-flanked neomycin cassette as wells a one loxP site upstream of exon 4 and one loxP site downstream of exon 5. Flp-mediated recombination removed the selection cassette and left exons 4 and 5 floxed. (J:298381)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any C9orf72 Mutation: 41 strains or lines available

References

• Original: J:298381 Koppers M, et al., C9orf72 ablation in mice does not cause motor neuron degeneration or motor deficits. Ann Neurol. 2015 Sep;78(3):426-38
• All: 4 reference(s)