Fbln1^tm1.1Cmusc
Targeted Allele Detail

Summary

• Symbol: Fbln1^tm1.1Cmusc
• Name: fibulin 1; targeted mutation 1, Marion Cooley
• MGI ID: MGI:6850728
• Synonyms: Fbln1c^-
• Gene: Fbln1 Location: Chr15:85090150-85170495 bp, + strand Genetic Position: Chr15, 40.27 cM, cytoband E-F
• Alliance: Fbln1^tm1.1Cmusc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:263505
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Modified isoform(s))
• Mutations: Insertion, Intragenic deletion
• Mutation details: The targeting cassette replaced exon 15 with a floxed neomycin resistance cassette. Cre-mediated recombination removed the selection cassette. This allele fails to produced the c variant. (J:263505)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Fbln1 Mutation: 30 strains or lines available

References

• Original: J:263505 Liu G, et al., Fibulin-1 regulates the pathogenesis of tissue remodeling in respiratory diseases. JCI Insight. 2016 Jun 16;1(9):e86380
• All: 3 reference(s)