Adm^tm2Kmca
Targeted Allele Detail

Summary

• Symbol: Adm^tm2Kmca
• Name: adrenomedullin; targeted mutation 2, Kathleen M Caron
• MGI ID: MGI:6850125
• Synonyms: Adm^deltaPAMP
• Gene: Adm Location: Chr7:110226868-110229027 bp, + strand Genetic Position: Chr7, 57.7 cM
• Alliance: Adm^tm2Kmca page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:286466
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Modified isoform(s))
• Mutations: Insertion, Intragenic deletion
• Mutation details: A gene-targeting vector was generated containing the promoter and exon 1, intron 1, part of exon 2, part of exon 3, intron 3, and exon 4 of the Adm gene upstream of a BamH1 site and a neomycin resistance cassette. The finale allele lacks the coding sequence for the proadrenomedullin N-terminal 20 peptide. (J:286466)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Adm Mutation: 13 strains or lines available

References

• Original: J:286466 Matson BC, et al., Genetic loss of proadrenomedullin N-terminal 20 peptide (PAMP) in mice is compatible with survival. Peptides. 2019 Feb;112:96-100
• All: 1 reference(s)