Crebrf^em1Eek
Endonuclease-mediated Allele Detail

Summary

• Symbol: Crebrf^em1Eek
• Name: CREB3 regulatory factor; endonuclease-mediated mutation 1, Erin E Kershaw
• MGI ID: MGI:6850019
• Synonyms: Crebrf^R458Q
• Gene: Crebrf Location: Chr17:26934624-26995609 bp, + strand Genetic Position: Chr17, 13.5 cM, cytoband B1
• Alliance: Crebrf^em1Eek page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Single point mutation
• Mutation details: CRISPR-targeting introduced the mutation that produces the amino acid substitution arginine to glutamine at position 458 (R458Q). (J:317162)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Crebrf Mutation: 39 strains or lines available

References

• Original: J:317162 Kanshana JS, et al., A murine model of the human CREBRFR457Q obesity-risk variant does not influence energy or glucose homeostasis in response to nutritional stress. PLoS One. 2021;16(9):e0251895
• All: 1 reference(s)