Gt(ROSA)26Sor^{tm1(IL7R)Bsed}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(IL7R)Bsed}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Benedict Seddon
• MGI ID: MGI:6842533
• Synonyms: R26-hIL-7R
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(IL7R)Bsed} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:314998
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1(IL7R)Bsed} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  IL7R (3575)

  Il7r	(MGI:96562)

• Mutation details: A loxP-flanked STOP cassette and human IL7R were inserted into the locus. Cre-mediated removal of the STOP cassette allows expression of the inserted gene. (J:314998)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1062 strains or lines available

References

• Original: J:314998 Silva A, et al., Overexpression of wild-type IL-7Ralpha promotes T-cell acute lymphoblastic leukemia/lymphoma. Blood. 2021 Sep 23;138(12):1040-1052
• All: 1 reference(s)