Spo11^em1Rdco
Endonuclease-mediated Allele Detail

Summary

• Symbol: Spo11^em1Rdco
• Name: SPO11 initiator of meiotic double stranded breaks; endonuclease-mediated mutation 1, R Daniel Camerini-Otero
• MGI ID: MGI:6842527
• Synonyms: Spo11^-
• Gene: Spo11 Location: Chr2:172819493-172835369 bp, + strand Genetic Position: Chr2, 95.64 cM, cytoband H4
• Alliance: Spo11^em1Rdco page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Deletion
• Mutation details: The allele was generated by deleting the 13 kb Spo11 genomic locus with CRISPR/Cas9 technology. This is a null allelel. (J:316849)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Spo11 Mutation: 21 strains or lines available

References

• Original: J:316849 Pratto F, et al., Meiotic recombination mirrors patterns of germline replication in mice and humans. Cell. 2021 Aug 5;184(16):4251-4267.e20
• All: 1 reference(s)