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Ace2em2(ACE2/GFP)Mlkn
Endonuclease-mediated Allele Detail
Summary
Symbol: Ace2em2(ACE2/GFP)Mlkn
Name: angiotensin I converting enzyme (peptidyl-dipeptidase A) 2; endonuclease-mediated mutation 2, Mark L Kahn
MGI ID: MGI:6842319
Synonyms: hACE2-GFPfl
Gene: Ace2  Location: ChrX:162922338-162971414 bp, + strand  Genetic Position: ChrX, 76.12 cM, cytoband F5
Alliance: Ace2em2(ACE2/GFP)Mlkn page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:315719
Parent Cell Line:  v6.5 (ES Cell)
Strain of Origin:  (C57BL/6 x 129S4/SvJae)F1
Mutation
description
Allele Type:    Endonuclease-mediated (Conditional ready, Humanized sequence, Inserted expressed sequence, Null/knockout, Reporter)
Mutation:    Insertion
 
Ace2em2(ACE2/GFP)Mlkn expresses 1 gene
 
Mutation detailsCRISPR/cas9 meditated recombination inserted a cassette containing a modified human ACE2 cDNA fused to an monomeric-Emerald GFP reported gene, loxP site, woodchuck hepatitis virus post-transcriptional regulatory element, simian virus 40 polyA sequence, loxP site, and an FRT-flanked PGK-neo and loxP site directly after the ATG site in exon 2. The human ACE2 cDNA was modified to use the mouse Ace2 signal peptide and codon optimized for mouse. (J:315719)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ace2 Mutation:  36 strains or lines available
References
Original:  J:315719 Tang AT, et al., SARS-CoV-2 infection olfactory cells and neurons drives acute lung injury and lethal COVID-19 in mice. bioRxiv. 2021 Dec;
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/26/2022
MGI 6.22
The Jackson Laboratory