Map3k13^em1Yjin
Endonuclease-mediated Allele Detail

Summary

• Symbol: Map3k13^em1Yjin
• Name: mitogen-activated protein kinase kinase kinase 13; endonuclease-mediated mutation 1, Yishin Jin
• MGI ID: MGI:6840986
• Synonyms: Map3k13^KO
• Gene: Map3k13 Location: Chr16:21643923-21752189 bp, + strand Genetic Position: Chr16, 12.92 cM
• Alliance: Map3k13^em1Yjin page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Using CRISPR-Cas9 technology, sgRNA sequences targeted to the kinase domain of the Map3k13 gene were designed. Two KO mouse lines were obtained and the one containing a deletion of the entire kinase domain was used in this study. (J:316717)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Map3k13 Mutation: 52 strains or lines available

References

• Original: J:316717 Li Y, et al., Activation of MAP3K DLK and LZK in Purkinje cells causes rapid and slow degeneration depending on signaling strength. Elife. 2021 Jan 21;10:e63509
• All: 1 reference(s)