Eef2k^tm1Kobir
Targeted Allele Detail

Summary

• Symbol: Eef2k^tm1Kobir
• Name: eukaryotic elongation factor-2 kinase; targeted mutation 1, Kobi Rosenblum
• MGI ID: MGI:6840224
• Synonyms: Eef2k^D273A, eEF2K^ki
• Gene: Eef2k Location: Chr7:120442080-120506441 bp, + strand Genetic Position: Chr7, 64.95 cM, cytoband F3
• Alliance: Eef2k^tm1Kobir page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:316669
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: The targeting construct inserted upstream of exon 7 a floxed wild-type mini gene encoding exons 7 through 18 and the 3 UTR, and an FRT-flanked neomycin resistance cassette. Exon 8 was modified to encode the amino acid substitution of aspartic acid to alanine at position 273 (D273A). (J:316669)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Eef2k Mutation: 43 strains or lines available

References

• Original: J:316669 Gildish I, et al., Impaired associative taste learning and abnormal brain activation in kinase-defective eEF2K mice. Learn Mem. 2012 Feb 24;19(3):116-25
• All: 2 reference(s)