Mt3^em1Ksvi
Endonuclease-mediated Allele Detail

Summary

• Symbol: Mt3^em1Ksvi
• Name: metallothionein 3; endonuclease-mediated mutation 1, Kavitha Subramanian Vignesh
• MGI ID: MGI:6838382
• Synonyms: Mt3^fl
• Gene: Mt3 Location: Chr8:94879235-94880774 bp, + strand Genetic Position: Chr8, 46.29 cM
• Alliance: Mt3^em1Ksvi page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready)
• Mutation: Insertion
• Mutation details: Using the CRISPR-Cas9 gene targeting approach, loxp sites were inserted into the murine Mt3 gene surrounding exon 3. (J:316444)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mt3 Mutation: 5 strains or lines available

References

• Original: J:316444 Chowdhury D, et al., Metallothionein 3-Zinc Axis Suppresses Caspase-11 Inflammasome Activation and Impairs Antibacterial Immunity. Front Immunol. 2021;12:755961
• All: 1 reference(s)