Tg(Prrx1-Shh*C25S)#Ptch
Transgene Detail

Summary

• Symbol: Tg(Prrx1-Shh*C25S)#Ptch
• Name: transgene insertion, Pao-Tien Chuang
• MGI ID: MGI:6836753
• Transgene: Tg(Prrx1-Shh*C25S)#Ptch Location: unknown
• Alliance: Tg(Prrx1-Shh*C25S)#Ptch page

Transgene origin

• Strain of Origin: Not Applicable

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Prrx1-Shh*C25S)#Ptch expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Shh (MGI:98297)	"mouse enhancer, modified mouse cDNA"

• Mutation details: A mouse sonic hedgehog cDNA with a p.C25S mutation (to prevent palmitoylation of the peptide) was placed under the control of the mouse paired related homeobox 1 enhancer to drive its expression in embryonic limb buds. (J:89228)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:89228 Chen MH, et al., Palmitoylation is required for the production of a soluble multimeric Hedgehog protein complex and long-range signaling in vertebrates. Genes Dev. 2004 Mar 15;18(6):641-59
• All: 1 reference(s)