Gt(ROSA)26Sor^{tm4(CAG-SMAD7)Thbr}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm4(CAG-SMAD7)Thbr}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 4, Thomas Braun
• MGI ID: MGI:6836738
• Synonyms: ROSA26^iSMAD7
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm4(CAG-SMAD7)Thbr} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:316413
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The targeting cassette inserted into the locus a CAG promoter driving conditional ubiquitous expression of a human V5-tagged SMAD7 coding sequence proceeded by a floxed stop cassette. (J:316413)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1084 strains or lines available

References

• Original: J:316413 Wang L, et al., BMP9 and BMP10 Act Directly on Vascular Smooth Muscle Cells for Generation and Maintenance of the Contractile State. Circulation. 2021 Apr 6;143(14):1394-1410
• All: 1 reference(s)