Tnfsf10^tm1.1Daav
Targeted Allele Detail

Summary

• Symbol: Tnfsf10^tm1.1Daav
• Name: tumor necrosis factor (ligand) superfamily, member 10; targeted mutation 1.1, Dario Vignali
• MGI ID: MGI:6835669
• Synonyms: Tnfsf10^L
• Gene: Tnfsf10 Location: Chr3:27371226-27393814 bp, + strand Genetic Position: Chr3, 10.82 cM, cytoband A3
• Alliance: Tnfsf10^tm1.1Daav page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:313420
• Parent Cell Line: JM8A3.N1 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting construct inserted a loxP site upstream of exon 2 and an FRT site, loxP site, 2A sequence, and a truncated (nonfunctional) NGFR reporter gene for cre-mediated deletion downstream of exon 5. FLP-mediated recombination removed the selection cassette inserted downstream of exon 5. NGFR expression is minimal even upon cre-mediated recombination thus cannot be used as intended. (J:313420)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tnfsf10 Mutation: 24 strains or lines available

References

• Original: J:313420 Dadey RE, et al., Regulatory T Cell-Derived TRAIL Is Not Required for Peripheral Tolerance. Immunohorizons. 2021 Jan 22;5(1):48-58
• All: 1 reference(s)