C5ar1^tm1.1Kohl
Targeted Allele Detail

Summary

• Symbol: C5ar1^tm1.1Kohl
• Name: complement component 5a receptor 1; targeted mutation 1.1, Jorg Kohl
• MGI ID: MGI:6835642
• Synonyms: GFP-C5aR1^flox
• Gene: C5ar1 Location: Chr7:15980668-15993465 bp, - strand Genetic Position: Chr7, 8.77 cM
• Alliance: C5ar1^tm1.1Kohl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:262501
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Conditional ready, Reporter)
• Mutation: Insertion
• Mutation details: A loxP site, FRT-flanked neomycin resistance gene, an Aequorea coerulescens GFP, and an internal ribosomal entry site was inserted adjacent to the 5'-end of exon 2 and a second loxP site was inserted downstream of exon 2. The neomycin was removed via Flp-mediated recombination. (J:262501)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any C5ar1 Mutation: 27 strains or lines available

References

• Original: J:262501 Karsten CM, et al., Monitoring and cell-specific deletion of C5aR1 using a novel floxed GFP-C5aR1 reporter knock-in mouse. J Immunol. 2015 Feb 15;194(4):1841-55
• All: 8 reference(s)