Helq^em1Xyz
Endonuclease-mediated Allele Detail

Summary

• Symbol: Helq^em1Xyz
• Name: helicase, POLQ-like; endonuclease-mediated mutation 1, Xiao-Yang Zhao
• MGI ID: MGI:6833990
• Synonyms: Helq-KO
• Gene: Helq Location: Chr5:100910011-100946464 bp, - strand Genetic Position: Chr5, 48.52 cM, cytoband E
• Alliance: Helq^em1Xyz page

Mutation origin

• Strain of Origin: Not Applicable

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Using CRISPR/Cas9 technology, the first exon of the Helq gene was targeted to induce 8-nt deletion in mouse BVSC ESCs. The targeted ESCs with 8-nt deletion in the two alleles of Helq gene were injected into blastocysts to generate chimeric mice. (J:316098)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Helq Mutation: 49 strains or lines available

References

• Original: J:316098 Zhao J, et al., Cell-fate transition and determination analysis of mouse male germ cells throughout development. Nat Commun. 2021 Nov 25;12(1):6839
• All: 1 reference(s)