Plcd1^em1Smoc
Endonuclease-mediated Allele Detail

Summary

• Symbol: Plcd1^em1Smoc
• Name: phospholipase C, delta 1; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
• MGI ID: MGI:6833985
• Synonyms: Plcd1^E396K
• Gene: Plcd1 Location: Chr9:118900595-118922570 bp, - strand Genetic Position: Chr9, 71.32 cM
• Alliance: Plcd1^em1Smoc page

Mutation origin

• Strain of Origin: Not Applicable

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Single point mutation
• Mutation details: CRISPR-targeting introduced a point mutation (C to T) that results in the amino acid substitution of glutamic acid with lysine at position 396 (E396K). (J:314315)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Plcd1 Mutation: 44 strains or lines available

References

• Original: J:314315 Liu K, et al., Germline Mutation of PLCD1 Contributes to Human Multiple Pilomatricomas through Protein Kinase D/Extracellular Signal-Regulated Kinase1/2 Cascade and TRPV6. J Invest Dermatol. 2021 Mar;141(3):533-544
• All: 1 reference(s)