Tigit^tm1.2Mrl
Targeted Allele Detail

Summary

• Symbol: Tigit^tm1.2Mrl
• Name: T cell immunoreceptor with Ig and ITIM domains; targeted mutation 1.2, Merck Research Laboratory
• MGI ID: MGI:6833889
• Gene: Tigit Location: Chr16:43469230-43484509 bp, - strand Genetic Position: Chr16, 28.44 cM
• Alliance: Tigit^tm1.2Mrl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:314544
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2 and 3 was flanked by loxP sites (size of loxP-flanked region: 3.9 kb). Positive selection markers was flanked by FRT (Neomycin resistance - NeoR) and F3 (Puromycin resistance - PuroR) sites and were inserted into intron 1 and intron 3, respectively. Flp-mediated recombination removed the selection cassette. Cre-mediated recombination removed exons 2 and 3. (J:314544)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tigit Mutation: 15 strains or lines available

References

• Original: J:314544 Han JH, et al., Effective Anti-tumor Response by TIGIT Blockade Associated With FcgammaR Engagement and Myeloid Cell Activation. Front Immunol. 2020;11:573405
• All: 1 reference(s)