Gt(ROSA)26Sor^{tm2(Vangl2*)Yy}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm2(Vangl2*)Yy}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 2, Yingzi Yang
• MGI ID: MGI:6833868
• Synonyms: Vangl2^A
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm2(Vangl2*)Yy} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:314584
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129 x C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready, Epitope tag, Inserted expressed sequence)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm2(Vangl2*)Yy} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Vangl2 (MGI:2135272)	all phosphorylation sites in two clusters are mutated to alanines

• Mutation details: A loxP-flanked PGK-neomycin cassette and 3x HA-tagged mouse phospho-mutant Vangl2 cDNA in which all phosphorylation sites identified in two clusters of Vangl2 were mutated to alanines were inserted into the locus. Expression can be induced by cre-mediated excision of the loxP-flanked stop cassette. (J:314584)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1083 strains or lines available

References

• Original: J:314584 Yang W, et al., Wnt-induced Vangl2 phosphorylation is dose-dependently required for planar cell polarity in mammalian development. Cell Res. 2017 Dec;27(12):1466-1484
• All: 1 reference(s)