Ptpn22^em1Kmow
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ptpn22^em1Kmow
• Name: protein tyrosine phosphatase, non-receptor type 22 (lymphoid); endonuclease-mediated mutation 1, Kerri Mowen
• MGI ID: MGI:6832841
• Synonyms: Ptpn22 619WW
• Gene: Ptpn22 Location: Chr3:103767111-103819563 bp, + strand Genetic Position: Chr3, 45.52 cM, cytoband F3
• Alliance: Ptpn22^em1Kmow page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Humanized sequence)
• Mutation: Single point mutation
• Mutation details: CRISPR/cas9 genome editing is used to create an amino acid substitution at position 619 (arginine to tryptophan, CGG to TGG, R619W) in exon 14 and a silent mutation (CTC to CTT) introduced at amino acid position 616 to create a BspE1 restriction site. (J:341570)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ptpn22 Mutation: 50 strains or lines available

References

• Original: J:341570 Orozco RC, et al., Proautoimmune Allele of Tyrosine Phosphatase, PTPN22, Enhances Tumor Immunity. J Immunol. 2021 Sep 15;207(6):1662-1671
• All: 2 reference(s)