Nrip1^tm1.2Ry
Targeted Allele Detail

Summary

• Symbol: Nrip1^tm1.2Ry
• Name: nuclear receptor interacting protein 1; targeted mutation 1.2, Rong Yuan
• MGI ID: MGI:6830913
• Synonyms: RY-Nrip^-
• Gene: Nrip1 Location: Chr16:76084288-76170715 bp, - strand Genetic Position: Chr16, 43.65 cM
• Alliance: Nrip1^tm1.2Ry page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:315111
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 4 was flanked by loxP sites. An FRT-flanked PGK-neomycin selection cassette was inserted upstream of exon 4 before the first lox site and was removed via Flp-mediated recombination. Exon 4 was deleted via cre-mediated recombination. (J:315111)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nrip1 Mutation: 195 strains or lines available

References

• Original: J:315111 Wang J, et al., Deletion of Nrip1 Extends Female Mice Longevity, Increases Autophagy, and Delays Cell Senescence. J Gerontol A Biol Sci Med Sci. 2018 Jun 14;73(7):882-892
• All: 1 reference(s)