Axin1^tm1.1Tcd
Targeted Allele Detail

Summary

• Symbol: Axin1^tm1.1Tcd
• Name: axin 1; targeted mutation 1.1, Trevor C Dale
• MGI ID: MGI:6830537
• Synonyms: Axin1^fl
• Gene: Axin1 Location: Chr17:26357662-26414785 bp, + strand Genetic Position: Chr17, 13.07 cM
• Alliance: Axin1^tm1.1Tcd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:314583
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 2 was flanked by loxP sites. An FRT-flanked neomycin selection cassette was inserted downstream of the floxed exon and was removed via Flp-mediated recombination. (J:314583)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Axin1 Mutation: 42 strains or lines available

References

• Original: J:314583 Feng GJ, et al., Conditional disruption of Axin1 leads to development of liver tumors in mice. Gastroenterology. 2012 Dec;143(6):1650-9
• All: 2 reference(s)