In(6Tmem176b;Tmem176a)1Ced
Endonuclease-mediated Allele Detail

Summary

• Symbol: In(6Tmem176b;Tmem176a)1Ced
• Name: inversion, Chr 6, Cedric Louvet 1
• MGI ID: MGI:6828964
• Gene: In(6Tmem176b;Tmem176a)1Ced Location: unknown Genetic Position: Chr6, Syntenic

Mutation origin

• Strain of Origin: (C57BL/6J x DBA/2J)F1

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Inversion
• Mutation details: CRISPR-targeting of exon 2 in both genes inverted the intervening sequence (4.2 kb) along with deleting 17 nucleotides from Tmem176b and 27 nucleotides from Tmem176a. (J:314921)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any In(6Tmem176b;Tmem176a)1Ced Mutation: 0 strains or lines available

References

• Original: J:314921 Lemoine A, et al., Generation of a Double KO Mouse by Simultaneous Targeting of the Neighboring Genes Tmem176a and Tmem176b Using CRISPR/Cas9: Key Steps from Design to Genotyping. J Genet Genomics. 2016;43(5):329-40
• All: 1 reference(s)