Ppt1^tm1.1Zhaow
Targeted Allele Detail

Summary

• Symbol: Ppt1^tm1.1Zhaow
• Name: palmitoyl-protein thioesterase 1; targeted mutation 1.1, Wenzhen Zhao
• MGI ID: MGI:6828731
• Synonyms: Ppt1^loxP
• Gene: Ppt1 Location: Chr4:122730035-122752968 bp, + strand Genetic Position: Chr4, 57.27 cM, cytoband D1-D3
• Alliance: Ppt1^tm1.1Zhaow page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:294414
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 4 and an FRT-flanked neomycin cassette and second loxP site were inserted downstream of exon 4. The neomycin cassette was removed via Flp-mediated recombination, leaving exon 4 floxed. (J:294414)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ppt1 Mutation: 19 strains or lines available

References

• Original: J:294414 Zhao W, et al., Functional importance of palmitoyl protein thioesterase 1 (PPT1) expression by Sertoli cells in mediating cholesterol metabolism and maintenance of sperm quality. Mol Reprod Dev. 2019 Aug;86(8):984-998
• All: 1 reference(s)