Plgrkt^tm2.1Lmls
Targeted Allele Detail

Summary

• Symbol: Plgrkt^tm2.1Lmls
• Name: plasminogen receptor, C-terminal lysine transmembrane protein; targeted mutation 2.1, Lindsey Miles
• MGI ID: MGI:6827449
• Synonyms: Plg-RKT^flox, Plgrkt^tm1.1Vlp
• Gene: Plgrkt Location: Chr19:29326004-29339340 bp, - strand Genetic Position: Chr19, 23.85 cM
• Alliance: Plgrkt^tm2.1Lmls page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:297274
• Parent Cell Line: iTL BA1 (ES Cell)
• Strain of Origin: (C57BL/6NTac x 129S6/SvEvTac)F1

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: Using homologous recombination in ES cells, FRT flanked neo cassette and loxP was inserted upstream of the exon 5 of the Plgrkt gene and another loxP was inserted into the intron downstream of the exon 7. The neo cassette was removed by crossing with FLP mice. (J:297274)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Plgrkt Mutation: 8 strains or lines available

References

• Original: J:297274 Vago JP, et al., Plasminogen and the Plasminogen Receptor, Plg-RKT, Regulate Macrophage Phenotypic, and Functional Changes. Front Immunol. 2019;10:1458
• All: 2 reference(s)