Xbp1^tm1Yolu
Targeted Allele Detail

Summary

• Symbol: Xbp1^tm1Yolu
• Name: X-box binding protein 1; targeted mutation 1, Yongbo Lu
• MGI ID: MGI:6827385
• Synonyms: Xbp1^CS
• Gene: Xbp1 Location: Chr11:5470659-5475893 bp, + strand Genetic Position: Chr11, 3.61 cM
• Alliance: Xbp1^tm1Yolu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:314673
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: Using homologous recombination in ES cells, the targeting vector inserted an Frt flanked neomycin cassette downstream of Xbp1 exon 5, two loxP sites flanking the exons 4 and 5 together with the neo-cassette, and a modified version of Xbp1 exon 4 (E426) along with exon 5 was positioned downstream of the second loxP site. The exon E426 is devoid of the intronic sequence of 26 nucleotides. (J:314673)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Xbp1 Mutation: 30 strains or lines available

References

• Original: J:314673 Xu Q, et al., Constitutive expression of spliced XBP1 causes perinatal lethality in mice. Genesis. 2021 Apr 23;:e23420
• All: 2 reference(s)