C9orf72^em2.1Aisa
Endonuclease-mediated Allele Detail

Summary

• Symbol: C9orf72^em2.1Aisa
• Name: C9orf72, member of C9orf72-SMCR8 complex; endonuclease-mediated mutation 2.1, Adrian Isaacs
• MGI ID: MGI:6827370
• Synonyms: C9orf72^{em1.1(GR400)Aisa}
• Gene: C9orf72 Location: Chr4:35191285-35226153 bp, - strand Genetic Position: Chr4, 17.13 cM
• Alliance: C9orf72^em2.1Aisa page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Not Applicable)
• Mutation: Insertion
• Mutation details: CRISPR-targeting introduced 400 codon optimized GR repeats directly downstream of the ATG start codon. An FRT site flanked neomycin-PGK selection cassette was inserted at the 3 end of the transgene. Flp-mediated recombination removed the neomycin-PGK cassette. (J:82809)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any C9orf72 Mutation: 43 strains or lines available

References

• Original: J:82809 European Mouse Mutant Archive, Information obtained from the European Mouse Mutant Archive (EMMA). Unpublished. 2003-2013
• All: 2 reference(s)