Slc9a6^tm1.1Her
Targeted Allele Detail

Summary

• Symbol: Slc9a6^tm1.1Her
• Name: solute carrier family 9 (sodium/hydrogen exchanger), member 6; targeted mutation 1.1, Joachim Herz
• MGI ID: MGI:6827307
• Synonyms: Nhe6^-
• Gene: Slc9a6 Location: ChrX:55655117-55709590 bp, + strand Genetic Position: ChrX, 30.06 cM
• Alliance: Slc9a6^tm1.1Her page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:312384
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 1 and a loxP/FRT-flanked neomycin resistance cassette was inserted downstream of exon 1. Cre-mediated recombination removed the neomycin cassette and deleted exon 1 in the germline. (J:312384)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc9a6 Mutation: 10 strains or lines available

References

• Original: J:312384 Pohlkamp T, et al., NHE6 depletion corrects ApoE4-mediated synaptic impairments and reduces amyloid plaque load. Elife. 2021 Oct 7;10:e72034
• All: 1 reference(s)