P2rx7^tm1.1Vvc
Targeted Allele Detail

Summary

• Symbol: P2rx7^tm1.1Vvc
• Name: purinergic receptor P2X, ligand-gated ion channel, 7; targeted mutation 1.1, Valerie Vouret-Craviari
• MGI ID: MGI:6827300
• Synonyms: p2rx7^loxP
• Gene: P2rx7 Location: Chr5:122781974-122829495 bp, + strand Genetic Position: Chr5, 62.5 cM, cytoband F
• Alliance: P2rx7^tm1.1Vvc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:301006
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: ES clones (C57/BL/6) containing a construct for the conditional elimination or re-expression of P2RX7 (purchased from The European Conditional Mouse Mutagenesis Program) were injected into blastocytes of C57Bl6/N. The chimeric mice were selected and crossed with Flp deleter mice. (J:301006)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any P2rx7 Mutation: 52 strains or lines available

References

• Original: J:301006 Douguet L, et al., A small-molecule P2RX7 activator promotes anti-tumor immune responses and sensitizes lung tumor to immunotherapy. Nat Commun. 2021 Jan 28;12(1):653
• All: 1 reference(s)