Prkce^tm1.1Akv
Targeted Allele Detail

Summary

• Symbol: Prkce^tm1.1Akv
• Name: protein kinase C, epsilon; targeted mutation 1.1, Ajit K Verma
• MGI ID: MGI:6827171
• Synonyms: PKCepsilon^LoxP
• Gene: Prkce Location: Chr17:86475213-86965347 bp, + strand Genetic Position: Chr17, 56.74 cM
• Alliance: Prkce^tm1.1Akv page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:314542
• Parent Cell Line: JM8A3 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The targeting construct is designed to insert a loxP site upstream of exon 4 and a second loxP site, followed by an FRT-flanked neomycin downstream of exon 4. Removal of exon 4 results in a frameshift and the premature truncation of protein. Flp-mediated recombination removed the FRT-flanked neo cassette. (J:314542)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Prkce Mutation: 39 strains or lines available

References

• Original: J:314542 Hafeez BB, et al., Tissue-specific conditional PKCepsilon knockout mice: a model to precisely reveal PKCepsilon functional role in initiation, promotion and progression of cancer. Oncotarget. 2016 May 31;7(22):33069-80
• All: 1 reference(s)