Sox4^tm1.1Cmo
Targeted Allele Detail

Summary

• Symbol: Sox4^tm1.1Cmo
• Name: SRY (sex determining region Y)-box 4; targeted mutation 1, Crlos S Moreno
• MGI ID: MGI:6827133
• Synonyms: Sox4^flox
• Gene: Sox4 Location: Chr13:29132902-29137682 bp, - strand Genetic Position: Chr13, 12.87 cM, cytoband A3-A5
• Alliance: Sox4^tm1.1Cmo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:312333
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: Using homologous recombination in ES cells, the targeting vector inserted a single loxP into 5'UTR of the Sox4 gene, and a 3' loxP site followed by an frt-flanked neo cassette was inserted downstream of the single coding exon. The Neo cassette was removed by crossing to the Flp recombinase strain and deletion from the 3UTR was confirmed. (J:312333)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sox4 Mutation: 23 strains or lines available

References

• Original: J:312333 Wiles WG 4th, et al., Mutation of murine Sox4 untranslated regions results in partially penetrant perinatal lethality. In Vivo. 2014 Sep-Oct;28(5):709-18
• All: 1 reference(s)