Gt(ROSA)26Sor^{em1(CAG-Fndc5,-tdTomato)Jkche}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{em1(CAG-Fndc5,-tdTomato)Jkche}
• Name: gene trap ROSA 26, Philippe Soriano; endonuclease-mediated mutation 1, Jake J Chen
• MGI ID: MGI:6822322
• Synonyms: R26^IRS
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{em1(CAG-Fndc5,-tdTomato)Jkche} page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Mutation details: Using CRISPR/Cas9 technology, the cassette consisting of a floxed stop codon fused to mouse Fndc5 cDNA with polyadenylation signal and 2A-tdTomato, under the control of the CAG promoter was inserted into the intron1 of the Rosa26 locus. (J:312359)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1062 strains or lines available

References

• Original: J:312359 Li X, et al., Roles and Mechanisms of Irisin in Attenuating Pathological Features of Osteoarthritis. Front Cell Dev Biol. 2021;9:703670
• All: 1 reference(s)