Crh^tm1.1Lsz
Targeted Allele Detail

Summary

• Symbol: Crh^tm1.1Lsz
• Name: corticotropin releasing hormone; targeted mutation 1.1, Larry S Zweifel
• MGI ID: MGI:6810172
• Synonyms: Crh^lox
• Gene: Crh Location: Chr3:19747565-19749560 bp, - strand Genetic Position: Chr3, 5.75 cM
• Alliance: Crh^tm1.1Lsz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:253267
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A 5' loxP site was inserted approximately 150 bp upstream of the minimal promoter and a 3' loxP and FRT-flanked neomycin resistance gene were inserted approximately 300 bp downstream of the polyadenylation sequence. The neomycin resistance gene was removed via Flp-mediated recombination. (J:253267)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Crh Mutation: 39 strains or lines available

References

• Original: J:253267 Sanford CA, et al., A Central Amygdala CRF Circuit Facilitates Learning about Weak Threats. Neuron. 2017 Jan 4;93(1):164-178
• All: 2 reference(s)