Plekho1^tm1.1Gez
Targeted Allele Detail

Summary

• Symbol: Plekho1^tm1.1Gez
• Name: pleckstrin homology domain containing, family O member 1; targeted mutation 1.1, Ge Zhang
• MGI ID: MGI:6791386
• Synonyms: Plekho1^fl
• Gene: Plekho1 Location: Chr3:95896110-95903258 bp, - strand Genetic Position: Chr3, 41.65 cM, cytoband F2
• Alliance: Plekho1^tm1.1Gez page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:240968
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: Using homologous recombination in ES cells, LoxP sites flanking exon 36 of Plekho1 and neo cassette flanked by frt sites downstream of exon6 were inserted. The neo cassette was removed by crossing with flp deleter mice. (J:240968)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Plekho1 Mutation: 16 strains or lines available

References

• Original: J:240968 Liu J, et al., Increased PLEKHO1 within osteoblasts suppresses Smad-dependent BMP signaling to inhibit bone formation during aging. Aging Cell. 2017 Apr;16(2):360-376
• All: 1 reference(s)