Pparg^tm1.1Sakl
Targeted Allele Detail

Summary

• Symbol: Pparg^tm1.1Sakl
• Name: peroxisome proliferator activated receptor gamma; targeted mutation 1.1, Steven A Kliewer
• MGI ID: MGI:6791383
• Synonyms: PPARgamma-K107R
• Gene: Pparg Location: Chr6:115337912-115467360 bp, + strand Genetic Position: Chr6, 53.41 cM, cytoband E3-F1
• Alliance: Pparg^tm1.1Sakl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:269302
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6J)F1

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Single point mutation
• Mutation details: A mutation was engineered to change isoform 2 lysine codon 107 in exon 3 (AAA) to arginine (AGA)(p.K107R) and an FRT site flanked neomycin resistance gene cassette was inserted into intron 3. The neo cassette was removed through subsequent flp-mediated recombination. The mutation prevents SUMOylation of the residue in the encoded peptide. (J:269302)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pparg Mutation: 42 strains or lines available

References

• Original: J:269302 Katafuchi T, et al., PPARgamma-K107 SUMOylation regulates insulin sensitivity but not adiposity in mice. Proc Natl Acad Sci U S A. 2018 Nov 27;115(48):12102-12111
• All: 1 reference(s)