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Acss2em2Reh
Endonuclease-mediated Allele Detail
Summary
Symbol: Acss2em2Reh
Name: acyl-CoA synthetase short-chain family member 2; endonuclease-mediated mutation 2, Robert E Hammer
MGI ID: MGI:6790669
Synonyms: Acss2 PM
Gene: Acss2  Location: Chr2:155359963-155404663 bp, + strand  Genetic Position: Chr2, 77.26 cM, cytoband H2
Alliance: Acss2em2Reh page
Mutation
origin
Strain of Origin:  C57BL/6N
Mutation
description
Allele Type:    Endonuclease-mediated (Not Applicable)
Mutation:    Single point mutation
 
Mutation detailsCRISPR/Cas9 technology generated a single nucleotide deletion in the ABC domain and introduced a stop codon following addition of one nonnative amino acid residue (LPKTRSGKIMRR... to LPKTRSGKIS*). Immunohistochemistry shows that protein is present at minimal or undetectable levels in the kidney and liver, respectively and mRNA levels are reduced in kidney and liver. (J:312521)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Acss2 Mutation:  53 strains or lines available
References
Original:  J:312521 Nagati JS, et al., Mammalian acetate-dependent acetyl CoA synthetase 2 contains multiple protein destabilization and masking elements. J Biol Chem. 2021 Jul 31;297(3):101037
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/18/2025
MGI 6.24
The Jackson Laboratory