Acss2^em2Reh
Endonuclease-mediated Allele Detail

Summary

• Symbol: Acss2^em2Reh
• Name: acyl-CoA synthetase short-chain family member 2; endonuclease-mediated mutation 2, Robert E Hammer
• MGI ID: MGI:6790669
• Synonyms: Acss2 PM
• Gene: Acss2 Location: Chr2:155359963-155404663 bp, + strand Genetic Position: Chr2, 77.26 cM, cytoband H2
• Alliance: Acss2^em2Reh page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Not Applicable)
• Mutation: Single point mutation
• Mutation details: CRISPR/Cas9 technology generated a single nucleotide deletion in the ABC domain and introduced a stop codon following addition of one nonnative amino acid residue (LPKTRSGKIMRR... to LPKTRSGKIS*). Immunohistochemistry shows that protein is present at minimal or undetectable levels in the kidney and liver, respectively and mRNA levels are reduced in kidney and liver. (J:312521)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Acss2 Mutation: 53 strains or lines available

References

• Original: J:312521 Nagati JS, et al., Mammalian acetate-dependent acetyl CoA synthetase 2 contains multiple protein destabilization and masking elements. J Biol Chem. 2021 Jul 31;297(3):101037
• All: 1 reference(s)