Star^tm1.1Jcfc
Targeted Allele Detail

Summary

• Symbol: Star^tm1.1Jcfc
• Name: steroidogenic acute regulatory protein; targeted mutation 1.1, Jose C Fernandez-Checa
• MGI ID: MGI:6790656
• Synonyms: STARD1^f
• Gene: Star Location: Chr8:26298502-26306010 bp, + strand Genetic Position: Chr8, 14.17 cM
• Alliance: Star^tm1.1Jcfc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:289711
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129 x C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A EUCOMM targeting vector was used to generate a conditional allele. The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exons 2-5 at position 26301547. The critical exons 2 to 5 are thus flanked by loxP sites. The lacZ and neo cassette were removed through subsequent flp-mediated recombination. (J:289711)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Star Mutation: 15 strains or lines available

References

• Original: J:289711 Torres S, et al., Endoplasmic Reticulum Stress-Induced Upregulation of STARD1 Promotes Acetaminophen-Induced Acute Liver Failure. Gastroenterology. 2019 Aug;157(2):552-568
• All: 3 reference(s)