Hprt1^{tm1(Tek-NOX5_ibeta)Hwsc}
Targeted Allele Detail

Summary

• Symbol: Hprt1^{tm1(Tek-NOX5_ibeta)Hwsc}
• Name: hypoxanthine phosphoribosyltransferase 1; targeted mutation 1, Harald H H W Schmidt
• MGI ID: MGI:6790475
• Synonyms: NOX5-KI
• Gene: Hprt1 Location: ChrX:52077014-52110536 bp, + strand Genetic Position: ChrX, 29.31 cM, cytoband A6
• Alliance: Hprt1^{tm1(Tek-NOX5_ibeta)Hwsc} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:312460
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• The human NOX5 beta gene under the control of the Tek (Tie2) promoter was inserted into the locus. (J:312460)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hprt1 Mutation: 1280 strains or lines available

References

• Original: J:312460 Casas AI, et al., Calcium-dependent blood-brain barrier breakdown by NOX5 limits postreperfusion benefit in stroke. J Clin Invest. 2019 Mar 18;129(4):1772-1778
• All: 3 reference(s)