Pdcd1^tm2.1Shr
Targeted Allele Detail

Summary

• Symbol: Pdcd1^tm2.1Shr
• Name: programmed cell death 1; targeted mutation 2.1, Arlene H Sharpe
• MGI ID: MGI:6790246
• Synonyms: Pdcd1^fl, Pdcd1^L
• Gene: Pdcd1 Location: Chr1:93966027-93980278 bp, - strand Genetic Position: Chr1, 47.47 cM
• Alliance: Pdcd1^tm2.1Shr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:307777
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exons 2, 3, and 4, encoding the IgV, transmembrane, and first cytoplasmic exon of PD-1 were flanked by loxP sites. An frt-flanked neomycin selection cassette was removed via FLP1-mediated recombination. (J:307777)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pdcd1 Mutation: 48 strains or lines available

References

• Original: J:307777 Tan CL, et al., PD-1 restraint of regulatory T cell suppressive activity is critical for immune tolerance. J Exp Med. 2021 Jan 4;218(1)
• All: 5 reference(s)