Ank2^tm4.1Bnt
Targeted Allele Detail

Summary

• Symbol: Ank2^tm4.1Bnt
• Name: ankyrin 2, brain; targeted mutation 4.1, Vann Bennett
• MGI ID: MGI:6784039
• Synonyms: ABe37floxed, Ank2^440flox
• Gene: Ank2 Location: Chr3:126715261-127292999 bp, - strand Genetic Position: Chr3, 56.07 cM
• Alliance: Ank2^tm4.1Bnt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:277752
• Parent Cell Line: TL1/TL-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting construct floxed exon 37. Flp-mediated recombination removed the FRT-flanked neomycin resistance cassette. (J:277752)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ank2 Mutation: 184 strains or lines available

References

• Original: J:277752 Yang R, et al., ANK2 autism mutation targeting giant ankyrin-B promotes axon branching and ectopic connectivity. Proc Natl Acad Sci U S A. 2019 Jul 23;116(30):15262-15271
• All: 2 reference(s)