Dyrk1a^tm1.2Ics
Targeted Allele Detail

Summary

• Symbol: Dyrk1a^tm1.2Ics
• Name: dual-specificity tyrosine phosphorylation regulated kinase 1a; targeted mutation 1.2, Mouse Clinical Institute
• MGI ID: MGI:6783456
• Gene: Dyrk1a Location: Chr16:94370869-94496376 bp, + strand Genetic Position: Chr16, 55.3 cM
• Alliance: Dyrk1a^tm1.2Ics page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:311493
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 7 and an FRT-flanked neomycin selection cassette and second loxP site were inserted downstream of exon 7. The neomycin selection cassette was removed via flp-mediated recombination. Cre-mediated recombination in the germline removed exon 7. (J:311493)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dyrk1a Mutation: 113 strains or lines available

References

• Original: J:311493 Brault V, et al., Dyrk1a gene dosage in glutamatergic neurons has key effects in cognitive deficits observed in mouse models of MRD7 and Down syndrome. PLoS Genet. 2021 Sep;17(9):e1009777
• All: 2 reference(s)